Spatio-temporal coupling characteristics of ultrafast laser pulses are quantitatively tailored. An asymmetric microstructure is induced in the focal volume when the laser scans perpendicularly to the direction of the spatial chirp in fused silica. The tilted direction reverses when adding a Dove prism into the light path. The sign of the pulse front tilt can be turned from positive to negative by changing the group delay dispersion by steps. We reveal that the tilted direction of a microstructure depends on spatial chirp, and the interplay between spatio-temporal chirp leads to the change of tilted angles.